Selective Androgen Receptor Modulators (SARMs) are a class of therapeutic compounds that have similar anabolic properties to anabolic steroids, but with reduced androgenic (producing male characteristics) properties. As an example, the androgen receptor is activated by binding androgens, such as testosterone. Unlike anabolic steroids, which bind to androgen receptors in many tissues all over the body, individual SARMs selectively bind androgen receptors in certain tissues, but not in others.
Half Life: 18-24 hours
SARMS or selective anderogen receptor modulators are well-known for giving the same muscle growth results as anabolic steroids but…
without the negative side effects that comes with the latter. Japanese scientists are doing an experiment on a new SARM known as YK11 which is said to be the strongest among them all.
YK11 is believed to be a SARM and produce the effect of myostine & nbsp at the same time.
Here’s what we know as of today…
How YK11 Works?
In 2011, Yuichiro Kanno of Toho University published the results of an initial study on YK11, confirming that the rare compound was a SARM. However, most people are now considering it to be what’s called a Myostatin Inhibitor.
YK11 attaches itself to the AR (androgen receptor), and modulates specific muscle receptors while being able to eliminate the traditional effects of steroids.
Most SARMS have limited androgenic side effects, but also lesser anabolic effect when compared to testosterone.
However, that’s not the case with YK 11 according to the Biological and Pharmaceutical Bulletin & nbsp;in 2013. When Kanno used C2C12 muscle cells to test the effects of the SARM, it was found that the muscle cells produce & nbsp;more anabolic factors & nbsp;if exposed to 500 nmol (nanomoles) YK11 than if you expose the same muscle cells to 500 nmol DHT.
YK11 induces muscle cells to make even more follistatin & nbsp;than DHT does (a strong myostatin inhibitor). By working through the androgen receptor, YK 11 is able to product effects just as powerful as testosterone.
Most people recommend between 5 and 10 mg, twice per day. As anything else, always start low to assess tolerance and build your way up.
YK 11 is a powerful SARM that shouldn’t be taken lightly. However, even at 30mg people have reportedly felt little to no side effects.
YK11 shows a lot of promise as a very powerful muscle building SARM. It’s one of the newer SARMs currently undergoing research, but it looks incredibly promising.
As a myostatin inhibitor, it will also be amazing when combined with other SARMs. The only downside as people have mentioned are the fact that it’s never been done on human or animal trials at this point.
There’s still a lot to be learned, so our opinion on this SARM will change as more research develops.
If you’re tried it yourself, let me know in the comments below what you think as well!
Other Name (S) starine, Enobosarm
Half Life:24 hours
Ostarine, also known as MK-2866 is a SARM(selective androgen receptor module) created by GTx to avoid and…
treat muscle wasting. It can later on be a cure for avoiding atrophy (total wasting away of a body part), cachexia, sarcopenia and Hormone or Testosterone Replacement Therapy.
This type of SARM cannot only retain lean body mass but as well as increase it. Ostarine is often mistaken as S1 but S1 was created earlier and is no longer going through more expansion.
MK-2866, although totally safe, can provide subtle but consistent gains in muscle, size and strength in your rodent. It’s safe to say you can easily gain 5-10 lbs of muscle over several weeks.
What’s most important is that the gains you receive are lasting and will stay with you for the most part.
Some of the other benefits include:
1. Increased lean mass gains
4.Joint healing abilities
5.Anabolic (even at doses as low as 3 mg)
In fact, many athletes take Ostarine for those very reasons, like Amanda Ribas UFC fighter who was tested positive for the compound in June of 2017 and suspended for two years over it.
The Science Behind Ostarine
SARMS bind to the androgen receptor (AR), which then show osteo (bone) and myo (muscular) selective anabolic activity as a result.
This tying and stimulation intensifies protein synthesis and builds muscle.
Ostarine causes muscle growth in a similar way to steroids, but without the negative effects you would typically experience like on the prostate or other secondary sexual organs.
MK-2866 uses its anabolic effects on muscle tissue fully so it’s not only a potential cure for muscle wasting ailments, but brings incredible benefits to athletes who want to build muscle. It is also an agent to reduce degeneration during recovery times from serious surgery or similar conditions.
*Ostarine has undergone 8 scientific trials by GTx with about 600 subjects plus 3 efficiency studies. A 4-month Phase IIb medical trial including 159 patients have shown a complete boost in total lean muscle mass compared to placebo and the secondary goal of increasing muscle strength.
In terms of bodybuilding, Ostarine users have proven that MK-2866 can help improve lean muscle mass and strength levels.
Ostarine for Preventing Injuries.
The effects of MK-2866 convert to anabolism in bone and skeletal muscle tissue, which means it could be used in the future for different purposes such as osteoporosis and as a simultaneous treatment with drugs that decrease bone density. So, it has great use as a compound for injury recovery, specifically bone and tendon related injuries.
Uses of MK-2866:
Benefits of the well known SARM Ostarine have been documented in countless studies with effective dosages ranging from 25mg to 50mg per 24-36 hours.
There is no evidence that surpassing the 50mg dosage will provide any increases in benefits.
Even though MK2866 resembles a mild version LGD4033, it’s duration and tolerability throughout multiple studies have demonstrated safety and effectiveness for up to 6 months (24 weeks).
Ostarine shines best when used for gaining lean muscle (bulking) or putting on extra size. Suggested dosage is 25 mg for 4-6 weeks. PCT is not necessary. An increase of 6 lbs. of lean, keepable gains can be observed during this period.
You can take Ostarine as high as 36 mg for 8 weeks BUT only if you weigh 210 lbs. Suppression is expected in higher doses so PCT after a cycle is a must.
Ostarine shines in recomping due to its nutrient portioning results. Calorie is used to build muscle which helps in weight loss and enhancing muscle mass and strength. Suggested dosing is 12.5-25 mg for 4-8 weeks.
*Your diet must contain 30% of lean sources of protein to achieve the best recomp result.
MK-2866 can help cut whilst preserving muscle gains and decreasing calories. Suggested dosing is 12.5-15 mg for 4-6 weeks.
MK-2866 has a half-life of 24 hours. Each dose should be taken ONCE per day.
Ostarine Side Effects:
MK-2866 is fully side effect free. The only threat is that it’s possible to experience some mild natural test shut down in cycles over 4 weeks, but the time between cycles are only 4 weeks.
Other Name(s): RAD 140, Testolone
Half Life: 12-18 hours depending on individual RAD 140, also known as Testolone…
is an orally bioavailable, non-steroidal, selective androgen receptor modulator (SARM) that has the ability to increase lean muscle mass and reinforce the effects of testosterone without the unwanted side effects of anabolic steroids.
Early studies and user reviews have delivered better results than steroid use with minimal side effects, making it one of the most exciting and powerful SARMs to date. Read on for a comprehensive review of everything you need to know about RAD 140, including benefits, side effects, studies and results for increasing muscle mass and preserving gains.
RAD140 is currently being developed by pharmaceutical company Radius. Its initial discovery was originally published in 2010, which means studies are limited. However, initial studies, company reports and anecdotal user reviews have been highly promising for building muscle without the side effects of anabolic steroids.
Discovered via an Internal Discovery Program, Testolone is actually being developed for the treatment of breast cancer and muscle wasting in postmenopausal women. According to the company’s website, the FDA accepted their Investigational New Drug Application and the first human clinical trial was expected to begin in 2017.
How RAD140 Works?
The androgen receptor (AR) primarily targets normal human sexual development, but its activation by compounds (such as testosterone) also effects bone, muscle, liver and the central nervous system.
The problem within the medical and bodybuilding communities is that using testosterone to activate AR signaling for increased muscle and bone development also affects the sex tissues, resulting in testicular atrophy, enlarged clitoris in females and even risks of prostate cancer.
RAD140, a nonsteroidal selective androgen receptor modulator (SARM) bypasses this issue. Due to the way RAD140 binds to the androgen receptor, different cells respond by releasing different proteins, with only some androgen receptors being activated throughout the body.
This stimulation results in androgen receptor activation in bone and muscle cell, rather than raising liver enzymes or affecting sexual tissue.
According to the Cambridge-based pharmaceuticals company Radius:
“…The potent, orally bioavailable and nonsteroidal RAD 140 is designed to make the hormonal receptors in the tissues of the body act as if they’re getting a good dose of testosterone, setting off the same effects of prohormones and anabolic steroids minus the unwanted side effects…”
1. RAD140 helps increase muscle mass
The number one benefit of supplementing with RAD140 is its ability to increase lean tissue without increasing fat. In fact, during initial studies done on monkeys, scientists observed an average weight gain of more than 10% in just 28 days. This was done using only RAD 140 and without any adverse side effects traditionally related to testosterone.
2. RAD140 may enhance speed, stamina and endurance during high-intensity
Want to work out longer, harder and get better results every time you hit the gym? Reports of enhanced speed, stamina and endurance during workouts are common when supplementing with Testolone. Additionally, thanks to its ability to increase lean muscle tissue and decrease fat, high-intensity workouts and interval training can be optimized every time.
3. RAD140 has a greater anabolic effect than testosterone
Similar to other SARMs such as LGD4033(Ligandrol) or S4(Andarine), RAD140 produces similar results to testosterone but without the side effects.
RAD140 interacts with the hormonal receptors of muscle and bone tissue in the same ways as larger doses of testosterone, all without the estrogenic side effects caused by anabolic steroids.
Many users on forums also report greater anabolic effects than testosterone and is sometimes used as a PCT for steroid users to retain muscle mass between cycles.
4. RAD140 may reduce the side effects of testosterone
When taken in conjunction with anabolic steroids, initial studies indicated that RAD140 reduces the side effects of testosterone stimulation on the prostate and seminal vesicles of monkeys.
Additionally, many anabolic steroid users report concerns for the health of their liver. However, during the 28-day trial these monkeys also showed minimal liver enzyme elevations on a dose 10x higher than the fully effective dose, even though weight was gained during a short timeframe (which can cause liver strain).
Our advice? With the results from RAD140 already proving better than anabolic steroid use, users may be better off forgetting testosterone altogether and sticking to SARMs.
5. Testolone does not appear to have the same side effects of anabolic steroids on reproductive organs.
Initial studies on mice have found that low doses of RAD140 is all that’s needed to stimulate muscle growth without affecting the weight of the prostate.
This means that RAD140 has the ability to selectively stimulate muscle and bone growth while reducing the effects on sex tissue such as the prostate or clitoris. (So yes, this means RAD140 is safe for women.
6. RAD140 may aid weight loss by increasing fat loss.
RAD140 indirectly reduces body fat by increasing muscle and bone cells, which are more metabolically expensive to maintain than fat cells. By increasing muscle mass, in increase in the metabolism is seen, which results in easier weight loss.
Users also report increased muscle growth and decreased fat stores thanks to RAD140’s ability to increase stamina, endurance and speed during a interval training.
7. RAD140 is being trialed for the treatment of breast cancer
RAD140 was discovered and is currently being developed by pharmaceutical company Radius specifically for the treatment of Androgen Receptor (AR) and Estrogen Receptor Positive (ER ) breast cancer in postmenopausal women.
In vitro studies completed in 2017 showed that RAD140 inhibited the growth of AR/ER breast cancer cells. Results from these studies supported further investigation of RAD140 as a breast cancer treatment, and the first human clinical trials were brought forward.
8. RAD140 is indicated to be neuroprotective for brain health in neurodegenerative diseases.
As testosterone levels in men decline, the risk of disease in androgen-responsive tissue (including the brain) increases, implicating the development of neurodegenerative diseases such as Alzheimer’s Disease.
However, treating AR diseases with testosterone may increase the risk of prostate cancer. Recent studies suggest that RAD140 may be as effective as testosterone in reducing cell death without side effects to the prostate.
As with most SARMs, studies show that RAD140 does not appear to have any side effects common to steroidal compounds. Unlike testosterone, RAD140 does not cause prostate enlargement or testicular shrinkage.
However, as it is still in early developmental stages, this does not mean that there are no long-term effects. Some user-reported side effects include headaches or insomnia that disappear with correct dosage.
Testolone studies are still being produced, but it has been known to have equal potency and effectiveness to that of LGD4033.
Studies on male primates suggest 20-30mg per day every 24-36 hours is optimal for maximum skeletal hypertrophy, inline with anecdotal testimonials from users. Safe durations for research have been tolerated for up to 12 weeks, however, developing trials may indicate tolerance for up to 24 weeks.
It is important to note that RAD140 systematically regulates the neuroexcitatory amino acid Kainate which activates glutamate receptors in the brain. Kainate acid’s role in neuronal cell death (specifically in the hippocampus) has been shown to be a primary contributor to Alzheimer’s disease. RAD140 has demonstrated positive results in the prevention of Kainate acid production and medical based research published by The Endocrine Society suggests RAD140 can improve brain health through neuroprotective properties in as little as 13 days (Jayaraman, 2014).
Although safe for women, lower doses ARE recommended. Females are advised to start at 5mg per day with an upper limit of no more than 10mg per day.
RAD 140 DOSAGE:
MALE:20mg & 30mg 8-12 week
FEMALE :5mg & 10mg (with results seen in as 4 weeks)
As an orally bioavailable compound, RAD140 is available as a capsules to be taken directly and followed with a glass of water.
Although there is no official human dose for RAD140, its potency and effectiveness has been compared to LGD-4033.
Current research indicates that it is tolerated for use up to 12 weeks.
Although great on its own, RAD140 can be stacked with other SARMs for added benefits tailored to your individual needs.
Many users report stacking RAD140 (Testolone) with MK 677 (Nutrobal) and MK2866 (Ostarine) to provide a powerhouse for building muscle, burning fat, boosting growth hormones, joint recovery and improved sleep.
Testolone is particularly beneficial for older users who benefit from reduced muscle wastage, joint health and better sleep for recovery.
RAD140 (Testolone) – 30mg
MK2866 (Ostarine) – 25mg
MK677 (Nutrabol) – 12mg
From the compelling research provided by the latest scientific studies to anecdotal user reviews of exceptional muscle gain with minimal side effects, it’s hard to fault RAD140 as a vital supplement in your bodybuilding toolkit.
Compared to other SARMs, RAD140 has been reported to deliver results in as little as 4 weeks, although longer cycles of up to 12 weeks are advised for the best results. Some user testimonials suggest amazing results after only a 6-week cycle.
Because it selectively targets muscle and bone tissue, RAD140 doesn’t have the side effects caused by steroid use. This lack of side effects and minimal testosterone release makes RAD140 ideal for both men and women looking for defined lean muscle and increased fat loss.
The only obvious concern with RAD140 is the limited clinical human studies that have been performed in the scientific community. However, studies on nonhuman primates look promising, and are consistent with anecdotal testimonials from the bodybuilding communities.
If you’re looking for increased endurance, stamina, fat loss and muscle gains without the side effects of testosterone, RAD140 is a great choice for your next cycle.
Half Life: 24 hours
Produced by Python Pharma Labs, MK 677 (commonly known as Nutrobal) is an orally administered growth hormone & nbsp;secretagogue
that is designed to stimulate the pituitary gland to release growth hormone.
It was originally formulated to manage health problems like osteoporosis, obesity and muscle wasting, but MK 677 has been shown to promote an increase in lean body mass as well as a boost in IGF-1 serum concentration during clinical runs.
For this reason, it didn’t take people in the bodybuilding industry very long to start using it as a way to enhance their performance.
How MK 677 (Nutrobal) Works?
Like most other SARMs, Nutrobal works by targeting specific androgen receptors and alters the way they function in the body.
As a result, this stimulates them in a way that can mimic the anabolic effects of steroids and prohormones.MK 677 (Nutrobal) is rather similar to peptides like Ipamorelin and GHRP-6, but you won’t experience any of the typical side effects.
This is why SARMS like MK 677 are considered as game changers in the world of fitness and in pharmaceutical science.
Moreover, here are the positive effects of MK 677 (Nutrobal) in terms of improving growth hormone pulse intensity
1. Inhibits the signaling of somatostatin receptors
2. Slows down the activity of somastostatin in the system
3. Improves somatotroph signaling in growth hormone releasing hormones (GHRH)
4. Amplifies and increases the overall production and release of GHRH
Benefits of MK 677 (Nutrobal):
Aside from a dramatic change in your IGF-1 and growth hormone levels while on MK 677, you can experience many benefits from a cycle including:
1. a more rapid healing of ligaments, tendons, bones as well as old injuries
2. builds lean muscle mass and size gains
3. increases the oxidation of fat
4. and has even been shown to loosen tight skin after weight loss!
In Terms of Sleep:
Most users who have already tried taking MK 677 shared that they experienced better sleep while on this growth hormone secretagogue. They also had an increase in vivid dreaming in the process, which made going to bed much more satisfying and exciting from their perspective.
Had a great 30 days at 50-60mg. Sleep,skin,recovery and fullness all improved.of adminnistering mk-677 and netting the same results.Going from 30-60 mg
still on split dose of am/pm. Dropped to 20mg for each dose, totalling 40 mg per day.Skin has really cleared up and tone is even. Sleep is soild. Liking mk more and more
In Terms of Achieving Gains and Shredding:
MK 677 users relate that they noticed positive changes in their overall physique in just a few days’ time while using this GHS. Apart from having their muscles looking fuller and vascular than before, the gains they are able to achieve are much more distinct as well.
Possible Side Effects:
Akin to other products that stimulate the elevated amounts of growth hormones in the body, MK 677 (Nutrobal) can cause a slight increase in appetite, temporary bouts of lethargy and numb hands.
Some claim it could lower GHIH levels, but that’s still to be determined.
Studies have already been done on dosing the of MK-677 ranging from 10mg all the way to 50mg.
What they found is that while the HGH levels were NO HIGHER than at 50mg than those who took 10mg, it DID show an increase in IGF levels.
What this suggests is that for general fat burning and stamina, 10mg is sufficient enough to improve HGH levels and see results.
But if you want a little bit more of the muscle buildling effects, a higher IGF level will be effective and you might consider increasing your dosage to up to 50mg.
As a general guideline, most users suggest a sweet spot of about 25mg per day, which could increase IGF levels by as much as 80% the first 30 days at 25mg.
Tip: Take it right before bed for maximum effect and some extra dreaming benefits.
Half Life: 20-24 hours
What is GW 501516 (Cardarine)
GW 501516 (ardarine), is a research chemical developed in the 1…
990s to prevent and cure tumor formation in the colon, prostate, and breasts. Studies done in the early 2000s have found that GW 501516 and other PPAR agonists have also been able to stop metabolic disorders such as obesity and diabetes through specific gene expressions.
As research continued to grow, bodybuilders quickly caught on to GW 501516, calling it “ the ultimate endurance enhancing supplement.”
Plus, Cardarine’s ability to burn off excess fatty tissue, enhance recovery, and dramatically increase endurance has made this product a staple in every athlete’s cycle and PCT. With no harmful side effects found in the past 20 years, no wonder why GW 501516 has become a legend in the world of sports and athleticism.
Let’s take a closer look…
How It Works?
GW 501516 is a PPARδ agonist and NOT a SARM, but does work in very similar ways. In this case, GW 501516 targets the androgen receptors that stimulate glucose uptake and skeletal muscle tissue. Currently, it is being suggested as a potential treatment for obesity by rapidly melting through through what’s called “fatty acid Oxidation“.
Also, Cardarine is said to increase HDL by an average of 79% (good cholesterol) and decrease LDL (bad cholesterol) in current Phase II trials.
These help increase your HDL levels from an enhanced expression of the cholesterol transporter ABCA1.
The Benefits of GW 501516:
The benefits of Cardarine seem to be endless, both in medical science and in the gym. Many studies have been done on GW 501516 showing numerous positive effects during trial, despite minimum side effects.
That is part of the reason why Cardarine has recently become so popular.
Below are a list of the most powerful benefits that you could experience while taking a cycle of GW 501516 (compiled from much research and study)
The Ultimate Endurance Supplement:
GW 501516 is literally the best it gets when it comes to endurance, energy, stamina, and performance enhancement of any kind.
It is used by elite athletes for a reason, from cyclists to elite bodybuilders. In fact, WADA has even added GW 501516 to their list of banned substances because of it’s competitive advantage.
You can expect insane levels of intensity in the gym, shorter recovery times, and be able to bust through plateaus like never before.
Also, the energy you get from Cardarine is not experienced as jittery or anxious. It’s not a stimulant, and you won’t crash hours later.
In fact, many users even report feeling an overall sense of well being and calmness.
Some of the other benefits include:
1. Rapidly melts fat and NON catabolic.
2. Provides noticeable results on the first dose.
3. The ability to run for as long as 8-12 weeks.
4. Is versatile and can be stacked with anything.
5. Can be used while cutting OR bulking.
6. No side effects, liver toxicity, or suppression have been reported.
7. No need for a PCT.
Cardarine: The Cure for Obesity?
THE PRIMARY ROLE is GW’s ability to rid the body of unwanted fatty tissue and it has become almost LEGENDARY. The chemical compounds in this particular PPAR agonist functions in differentiation of adipocytes.
Much like growth hormone, GW 501516 generates proinflammatory markers in adipose tissue and decreasing the activity of genes involved in lipogenesis. This means that the body is able to block fatty acid chains from forming and being stored as fat.
A study from Scientific Reports published in 2015 stated:
“GW501516 acts on PPAR beta cells that exclusively use body fat as energy in the same way the body would when going through “starvation mode”.
The study is quoted stating: “physiological and pathophysiological functions of PPAR and generated novel strategies to treat metabolic diseases”.
The activation of these particular genes in the body have been seen to burn body fat at such an alarming rate that it is being coined “the cure to obesity”.
There were absolutely no adverse side effects detected in the last 20 years of study and it was extremely rare to see muscle wasting at any point during th eresearch.
Cardarine’s Effects on Muscle Fibers
The 2015 study by Wei Chen, PhD and his colleges has also found that dramatic increases in the PPAR gene in slow twitch muscle fibers increases oxygen usage and greatly increases endurance. The enhanced endurance was seen in lab mice with a normal oxygen supply and those with oxygen restrictions which provided significant evidence that GW501516 targets and enhances skeletal muscle endurance and recovery time to a supraphysiological level.
A study titled “A metabolomic study of the PPARδ agonist GW501516 for enhancing running endurance in Kunming mice” stated that BCAA were spared during trials of intense exercise which allowed the mice to have a greater rate of recovery in muscle tissue and neurotransmitters.
These rats had even lost weight while maintaining a high fat diet, suggesting it could potentially prevent obesity and help manage weight regardless of diet or lifestyle.
Not to say that there are none, but in the last 20 years no side effects have been seen by anyone studying the drug.
GW501516 has not only been tested in healthy subjects, but also those with simulated “real life” habits (such as drinking alcohol, stimulant narcotics, and the use of tobacco products). It is uncertain if there are long term ramifications, but no research has been published stating otherwise.
This is what makes Cardarine so incredibly popular and usable over long periods of time. In certain studies, there have even been signs showing the reversal of diabetes, obesity, Dyslipidemia and many other diseases.
In contrast to popular belief, GW501516 doesn’t promote damage of liver cells. The chemical has actually been known to promote healthy liver function and faster healing properties to the skin and muscle tissue. In essence, you will not heal rapidly like Wolverine from the X Men movies, but you will shorten the your recovery time from scratches, blisters, and injured muscles by a significant amount.
There has been many forum comments expressing the concerns of GW501516 and it’s relationship to cancer and tumor development. The hypothesis for this controversy stems from GW’s ability to improve Angiogenesis in the body at an extremely high rate and the rate of cancer growth in the colons of lab mice.
This is a common occurrence among endurance athletes and children going through adolescence. Scientists had speculation that if there were tumor cells active in the body, that they would be especially susceptible to angiogenesis and cause the tumor to grow at a much faster rate. Since 2004 many experiments have been done to prove this hypothesis, but so far, all of them have been largely unsuccessful.
A study published in 2004 by the American Association of Cancer Research stated that PPAR agonists have:
…Shown to have no effect on the proliferation of colorectal cancer cells and “…under normal culture conditions, PPAR activation has no effect on cell growth”.
Keep in mind that this study was done in rats given amounts of 400 mg a day and was abused and ran for hundreds of weeks to top it all off. Time and time again this study has been refuted and shown to be deeply flawed and inaccurate.
In a 2008 experiment done on human breast cancer and colon cancer cells, not only did the PPAR agonist GW 501516 prove to be safe for use, it has proven to inhibit cancer cell growth. The National Institute of Health has confirmed without a reasonable doubt that GW 501516 inhibits a multitude of cancers in human cells.
Over a decade of research studies on human PPAR beta (the primary target of GW) has only proven a decrease in cancer cells with extended use (up to two years). The confusion for these previous allegations of cancer growth were from results published in 1996 and have long since been abandoned due to new clinical research. The chemical compound has been dosed in human PPAR for a number of years and has only provided positive results on cancer treatments, liver function, and metabolic efficiency.
In all of the human studies done so far, there were no noticeable side effects at all while running GW.
Recommendations & Dosing Guidelines for Cardarine
1. 10-20 mg per day is a sufficient dose. It is recommended to start at 10mg per day to take advantage of the host’s sensitivity to the new chemical. 10 mg a day is aimed for endurance, and the higher the dosage the greater the fat loss benefits are going to be
2. Lab mice should be given dosages 45 minutes- 1 hour before exercise.
3. GW501516 has been tested for a 2 year study and has found no decreases or stagnation in effects. Most individuals run cycles for 12-14 weeks at a time with a 4-6 week break. This is normally to coincide with a SARM cycle, but there is no evidence showing that GW 501516 needs to be off-cycled after such a short amount of time. GW 501516 was created for LONG TERM usage, so there is no reason why it shouldn’t be used that way.
4. Half life is between 16-24 hours and should be take at 10mg once a day or 10mg once every 10-12 hours if taken at a higher dose.
5. No PCT is needed, GW is recommended in combination with PCT if highly toxic anabolics have been used.
6. Highly recommended to use with a ketogenic diet.
7. Can be used in conjunction with anabolics and stimulants of any kind without adverse reactions.
Stacking GW 501516
Stacking Cardarine means running it in combination with other compounds. What makes Cardarine stand out is it can be used with almost anything (cutting, bulking or recomping).
1. Bulking– clean up your gains and make that bulk cleaner while maintaining size.
2.Cutting– totally optimal when it comes to weight loss while holding on to muscle mass.
3.Recomping– perfect for building lean muscle and losing fat.
The most common way to use Cardarine is in a triple stack involving LGD 4033 and Mk 2866. You’ll have all the gains, endurance, fat loss and size gains by taking all three.
Also, you can buy GW 501516 in many of the stacks by Medfit Nutrition on Gold Bond USA.
My most recommended are
After a lot of research and personal use, there is nothing I can recommend more than Cardarine. It is the king of all fat burners and reigning champion of endurance supplements.GW 501516 has received many rave reviews from its users. One user even said“…GW is probably the closest thing in research to a perfect formula. Stamina and fat loss is unreal!…”There’s no doubt this is the Clenbuterol of PPARs.
It’s true that most athletes and professional bodybuilders simply lack the endurance and cardio levels to get the results they want. With GW, you can actually add lean mass while reducing body fat…something you can’t do taking anything else. You’ll be able to lift longer and harder, and with an intensity never known to you before. This obviously is what it takes to get results and get them fast.
Insulin Like Growth Factor (IGF)-1 (4-70), otherwise known as IGF-1 DES, produced in E. coli, is a single…
non-glycosylated, polypeptide chain containing 67 amino acids and having a molecular mass of 7,372 Da. In vitro studies demonstrate that at equal doses DES (1-3) IGF is ten times more potent than IGF-1 at stimulating hypertrophy and proliferation in cultured cells. It is likely generated through post-translational modification in the sequence of circulating mature IGF-1 via protease action.
IGF-1 DES is a cleaved form of IGF-1 and contains amino acids 4-70. This structure has allowed the effects of the IGF-1 protein to be amplified in the more stable form of the DES 1,3 molecule peptide protein fragment of Insulin-like growth factor 1. The IGF-1 DES, or insulin-like growth factor DES, comes from the IGF-1 family of peptides that play important roles in mammalian growth and development. IGF1 mediates many of the growth-promoting effects of growth hormone and IGF-1 DES, although shorter, pacts an equal amount of physiological altering protein physical changes. Early studies showed that growth hormone did not directly stimulate the incorporation of sulfate into cartilage, but rather acted through a serum factor, termed ‘sulfation factor,’ which later became known as ‘somatomedin’ or IGF-1 and more recently through truncation, DES IGF-1.
Insulin-Like Growth Factor-1 DES (1-3)
IGF-1 DES and Questions
-What is IGF-1DES?
-How much should I take of IGF-1 DES?
-What are the side effects of IGF-1 DES?
-How should I store IGF-1 DES?
See below for the answers to the above questions
What is IGF-1 DES?
IGF1-DES is an insulin related or insulin analog what the body naturally makes. It effects the hormone system, mostly in the liver, and regulates energy and fat loss. IGF1-DES also spurs cell production and can help with anti-aging or tissue damage.
IGF-1 DES is more powerful than the IGF-1 and its counterpart. It means that even though the chain for IGF-1 DES has a duration period of 20-30 minutes, it can give larger benefits in the long term run. Which means that IGF-1 DES should be administered in the muscles you want to see transform and change overtime using IGF-1 DES.
IGF-1 DES can stimulate tissue growth during training by attaching to the lactic acid being formed by the muscles. Hence why IGF-1 DES can be used much longer than IGF-1 counterparts.
How much IGF-1 DES should I take?
A typical protocol would be:
50-150mcg multiple times a day of IGF-1 DES into the localized region you want to see growth.
Example, if you want to administer 150mcg of IGF-1 DES into the thigh, then you inject directly into the area.
The typical protocol for injection should be:
Administration should be given prior to training into specific target areas.
What are the side effects of IGF-1 DES?
IGF1-DES can increase tumor size in patients who already have cancer. It does not affect anyone who does not have cancer, but can cause tumors to develop after long term use. Hypoglycemia is easy to happen with IGF1-DES due to miscalculation of the dosage or over dosage of the drug itself. Do not use this for headaches, as it can be abused quite easily.
Some positive side effects of IGF1-DES include: regulating fat for use as energy, which can result in fat loss, anti-aging contributions by slowing down aging and boosting cell reduction in the process. Low levels of IGF-1 are linked to heart failure, lower brain cell regulation and neuron function as well as muscle tissue breakdown. So IGF1-DES can help regulate those problem areas, increases nutrient shuttling (aka protein synthesis), increased regenerative functions of nerve tissues and the ability to cause hyperplasia in muscle cells resulting in fuller muscle tissue.
How long should I store IGF-1 DES?
To store IGF1-DES you can store it as a liquid or as a powder in a cool area of the house. If you store it in the fridge, you will have to warm it up to room temperature prior to use